Women At Risk During Pregnancy

Women who develop high blood pressure and other problems - called pre-eclampsia - during pregnancy, are more likely than other women to have reduced thyroid function (hypothyroidism), finds a study published on bmj.com today.

It may also put women at a greater risk of thyroid problems later in life.

Pre-eclampsia is a serious condition where abnormally high blood pressure and other disturbances develop in the second half of pregnancy.

Hypothyroidism is caused by insufficient production of hormones by the thyroid gland.

Although the exact cause of pre-eclampsia is still unclear, studies suggest that certain proteins may be responsible.

Levels of these proteins rise during the last two months of normal pregnancy and increase to very high concentrations in women with pre-eclampsia. Studies also suggest that women with a history of pre-eclampsia have an increased risk of future cardiovascular and kidney (renal) disease.

So, a research team based in the United States and Norway compared thyroid function in women who developed pre-eclampsia during pregnancy with those whose blood pressure remained normal.

They also tested whether pre-eclampsia in a previous pregnancy was associated with risk of reduced thyroid function in later life.

Their findings are based on thyroid function tests from 140 healthy pregnant women taking part in a US trial who developed pre-eclampsia, 140 matched controls in the same trial who did not develop pre-eclampsia, and 7,121 women in a Norwegian study who were monitored for around 20 years after their first pregnancy.

In the US study, levels of thyroid stimulating hormone measured just before delivery were twofold higher in women who developed pre-eclampsia during pregnancy compared with those who did not.

This was strongly associated with excess levels of a particular protein (tyrosine kinase), which plays a key role in the pathogenesis of pre-eclampsia.

In the Norwegian study, women who developed pre-eclampsia in their first pregnancy were more likely than other women to have high concentrations of thyroid stimulating hormone many years after the pregnancy. The association was particularly strong if pre-eclampsia had occurred in two pregnancies.

The authors conclude that women who develop pre-eclampsia are at a greater risk of hypothyroid function during their pregnancy and women with a history of pre-eclampsia are at greater risk of hypothyroid function many years later.

These findings could have important implications for the subsequent care of women with pre-eclampsia, they add.

Not only should they be followed closely for the development of cardiovascular and renal disease, but consideration should also be given to monitoring for the development of reduced thyroid function and clinically important hypothyroidism.

Treatment might also prevent early cardiovascular disease in women with a history of pre-eclampsia, they say.


Related UK National News Stories
Click here for the latest headlines.

17 February 2004
UK sees 20% increase in multiple births over 10 years
Mothers are having 20% more multiple births than they were a decade ago, according to figures released today by the Office for National Statistics (ONS). Statistics have revealed that in 2002, the multiple birth rate was 15 per 1,000 women giving birth, compared with 12.5 in 1992.
19 June 2014
Lowest Recorded Figures Of Women Smoking During Pregnancy
The Health and Social Care Information Centre (HSCIC) has said figures show a year-fall of 12.7% in the number of women smoking during pregnancy in England, indicating the lowest level on record. Rates have fallen 15.1% since 2006-2007 with a steady year-on-year decline up until the most recent figures. Figures vary depending on region, with a 5.
23 July 2010
Fifth Of Teens Pregnant At 18
One in five teenage girls has been pregnant at least once by the age of 18, according to the latest Government figures. The figures, from a Department of Education study of 8,500 teenagers, found that more than eight of ten boys and girls questioned said that they were sexually active by the time they turned 18.
01 September 2003
Major study launched into pregnancy discrimination at work
The Equal Opportunities Commission (EOC) has today launched the largest ever investigation into pregnancy discrimination at work. The announcement follows a survey from the infant charity Tommy's, that reported difficulties at work for pregnant women.
19 August 2014
New Data Shows Women Hit By 'Mid-Life Pay Crisis'
Female managers over 40 years old are earning 35% less than men, according to new data by the Chartered Management Institute (CMI) and XpertHR. To earn the same as a male manager over a career, a woman would have to work the equivalent of over 14 years more.